Estrés y función cognitivael papel de los glucocorticoides en procesos de aprendizaje y memoria
- Cordero, María Isabel 1
- Sandi, Carmen 1
-
1
Universidad Nacional de Educación a Distancia
info
ISSN: 1134-7937
Year of publication: 1998
Volume: 4
Issue: 1
Pages: 51-58
Type: Article
More publications in: Ansiedad y estrés
Abstract
Long-term memory storage is a selective process whereby a decision is made, at the neural level, about the type of information available at a learning experience that should be preserved in memory. The physiological systems involved in the organisms’ response to stress appear as potential modulators of memory formation. In particular, recent studies have indicated that the central actions of corticosteroids -the final products of the hypothalamus-pituitary-adrenal axis activation- are one of the mechanisms implicated in the formation of enduring memories. By acting through specific receptors, these hormones are able to modulate different aspects of neural and behavioural plasticity. In this work, we review the role of glucocorticoids (cortisol or corticosterone, depending on the animal specie) on certain cognitive processes, such as learning and memory formation.
Bibliographic References
- Bennett, M.C., Diamond, D.M., Fleshner, M. y Rose, G.M. (1991). Serum corticosterone level predicts the magnitude of hippocampal primed burst potentiation and depression in uretheaneanesthetized rats. Psychobiology, 19, 301-307.
- Bliss, T.V.P. y Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate gyrus of the anaesthetized rabbit following stimulation of the perforant path. Journal of Physiology, 232, 331-356.
- Cahill, L. y McGaugh, J.L. (1996). Modulation of memory storage. Current Opinion in Neurobioly, 6, 237-242.
- Cordero, M.I. y Sandi, C. (1998). A role for brain glucocorticoid receptors in contextual fear conditioning: dependence upon training intensity. Brain Research, 786, 11-17.
- Cordero, M.I., Merino, J.J. y Sandi, C. (1998). Correlational relationship between shock intensity and corticosterone secretion on the establishment and longterm retention of contextual fear conditioning. Behavioral Neuroscience, en prensa.
- Cherkin, A. (1969). Kinetics of memory consolidation. Role of amnesic treatment parameters. Procedings of the National Academy of Science. USA, 63, 1094-1101.
- Davis, M. (1992). The role of the amygdala in fear-potentiated startle: implications for animal mdels of anxiety. Trends Pharmacology Science, 13, 35-41.
- De Kloet, E.R., de Koch, S., Schild, V. y Veldhuis, H.D. (1988). Antiglucocorticoid RU38486 attenuates retention of a behavior and disinhibits the hypothalamicpituitary-adrenal axis at different sites. Neuroendocrinology, 47, 109-115.
- Dokas, L.A., Schlatter, L.K. y Barr, C.S. (1994). Corticosteroid-induced proteins in brain. En E.R. de Kloet, E.C. Azmitia y P.W. Landfield (Eds.), Annals of the New York Academy of Sciences, Vol. 746. Brain corticosteroid receptors. Studies on the mechanism, function and neurotoxicity of corticosteroid action (pp.157-163). New York.
- Fanselow, M.S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin and Reviews, 1, 429-438.
- Fanselow, M.S. y Bolles, R.C. (1979). Naloxone and shockelicited freezing in the rat. Journal of Comparative and Physiological Psychology, 93, 736-744.
- Fleshner, M., Pugh, C.R., Tremblay, D. y Rudy, J.W. (1997). DHE-S selectively impairs contextual-fear conditioning: support for the antiglucocorticoid hypothesis. Behavioral Neuroscience, 111, 512-517.
- Friedman, M.J., Charney, D.S. y Deutch A.Y. (Eds.) (1995). Neurobiological and clinical consequences of stress. From normal adaptation to posttraumatic stress disorder. Philadelphia: Lippincott-Raven.
- Hebb, D.O. (1949). The organisation of behavior. New York, Wiley.
- Jacobs, H.E. (1988). Yes, behaviour analysis can help, but do you know how to harness it? Brain Injury, 2, 339-346.
- Joëls, M. y de Kloet, E.R. (1992). Control of neuronal excitability by corticosteroid hormones. Trends in Neuroscience, 15, 25-30.
- Joëls, M. y de Kloet, E.R. (1994). Mineralocorticoid and glucocorticoid receptors in the brain: implications for ion permeability and transmitter systems. Progress in Neurobiology, 43, 1-36.
- Kim, J.J. y Fanselow, M.S. (1992). Modality-specific retrograde amnesia of fear. Science, 256, 675-676.
- LeDoux, J.E. (1993). Emotional memory systems in the brain. Behavioral Brain Research, 58, 1-3: 69-79.
- LeDoux, J.E. (1995). Setting “Stress” into Motion: Brain mechanisms of stimulus Evaluation. En M.J. Friedman, D.S. Charney y A.Y. Deutch. (Eds), Neurobiological and clinical consequences of stress. From normal adaptation to posttraumatic stress disorder (pp. 125-130). Philadelphia: Lippincott-Raven.
- Lupien, S.J. y McEwen, B.S. (1997). The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Research Reviews, 24, 1-27.
- Maren, S. y Baudry, M. (1995). Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory. Neurobiology of Learning and Memory, 63,1-18.
- McEwen, B.S. y Sapolsky, R.M. (1995). Stress and cognitive function. Current Opinion in Neurobiology, 5, 205-216.
- McGaugh, J.L. (1989). Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annual Review of Neuroscience, 12, 255-287.
- Micheau, J., Destrade, C. y Sourmireu-Mourat, B. (1985). Timedependent effects of posttraining intrahippocampal injections of corticosterone on retention of appetitive learning in mice. European Journal of Pharmacology,106, 39-46.
- Morris, R.G., Garrud, P., Rawlins, J.N.P. y O´Keefe, J. (1982). Place navegation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
- Nichols, N.R. y Finch, C.E. (1994). Gene products of corticosteroid action in hippocampus. En E.R. de Kloet, E.C. Azmitia y P.W. Landfield (Eds.), Annals of the New York Academy of Sciences, Vol. 746. Brain corticosteroid receptors. Studies on the mechanism, function and neurotoxicity of corticosteroid action (pp.145-154). New York.
- Ohman, A. (1992). SPR Aw. 1990. For distinguished contributions to psychophysiology: PJ Lang. Psychophysiology, 29, 1-17.
- Oitz, M.S. y de Kloet, E.R. (1992). Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behavioral Neuroscience, 106, 62-71.
- Papez, J.W. (1937). A proposed mechanism of emotion. Archives of Neurological Psychiatry, 38, 725-743.
- Phillips, R.G. y LeDoux, J.E. (1994). Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learning and Memory, 1, 34-35.
- Pugh, C.R., Fleshner, M. y Rudy, J.W. (1997a). Type II glucocorticoid receptor antagonists impair contextual but not auditoy-cued fear conditioning in juvenile rats. Neurobiology of Learning and Memory, 67, 75-79.
- Pugh, C.R., Tremblay, D., Fleshner, M. y Rudy, J.W. (1997b). A selective role of corticosterone in contextual-fear conditioning. Behavioral Neuroscience, 111, 503-511.
- Roozendaal, B. y McGaugh, J.L. (1995). Amygdaloid nuclei lesions differentially affect glucocorticoid-induced memory enhancement in an inhibitory avoidance task. Neurobiology of Learning and Memory, 65, 1-8.
- Roozendaal, B. y McGaugh, J.L. (1997a). Basolateral amygdala lesions block the memoryenhancing effects of glucocorticoid administration in the dorsalhippocampus of rats. European Journal of Neuroscience, 9, 76-83.
- Roozendaal, B. y McGaugh, J.L.(1997b). Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiology of Learning and Memory, 67, 176-179
- Sandi, C. y Rose, S.P.R. (1994a). Corticosteroid receptor antagonists are amnestic for passive avoidance learning in day-old chicks. European Journal of Neuroscience, 6, 1292-1297.
- Sandi, C. y Rose, S.P.R. (1994b). Corticosterone enhances longterm retention in one-day-old chicks trained in a weak passive avoidance learning paradigm. Brain Research, 647, 106-112.
- Sandi, C. y Rose, S.P.R. (1997). Training-dependent biphasic effects of corticosterone in memory formation for a passive avoidance task in chicks. Psychopharmacology, 133, 152-160.
- Sandi, C., Loscertales, M. y Guaza C. (1997). Experience-dependent facilitating effect of corticosterone on spatial memory formation in the water maze. European Journal of Neuroscience, 9, 637-642.
- Sandi, C., Rose, S.P.R., Mileusnic, R. y Lancashire, C. (1995). Corticosterone facilitates longterm memory formation via enhanced glycoprotein synthesis. Neuroscience, 69, 4, 1087-1093.
- Sandi, C., Venero, C. y Guaza, C. (1996). Novelty-related rapidlocomotor effects of corticosterone in rats. European Journal of Neuroscience, 8, 794-800.
- Sapolsky, R.M. (1996). Why stress is bad for your brain. Science, 273, 749-750.
- Selye, H. (1956). The Stress of Life, McGraw-Hill, Nueva York.
- Selye, H. (1980). Selye´s guide to stress research, Van Nostrand, Nueva York.
- Venero, C., Guaza, C. y Sandi, C. (1996). Regional and temporal modulation of brain glycoprotein synthesis by corticosterone. Neuroreport, 7, 15, 1-4.