Inhibición de la α-glucosidasa mediante flavonoides de origen natural como vía de control en el desarrollo de diabetes mellitus

  1. Rincón Silva, Juan David 1
  2. Rincon-Silva, Nelson Giovanny 2
  3. Acosta Vargas, Jairo Steffan 3
  1. 1 Universidad Pedagógica Nacional
    info

    Universidad Pedagógica Nacional

    Ciudad de México, México

    ROR https://ror.org/023m5rq87

  2. 2 Universitat de les Illes Balears
    info

    Universitat de les Illes Balears

    Palma, España

    ROR https://ror.org/03e10x626

  3. 3 Universidad de Alcalá
    info

    Universidad de Alcalá

    Alcalá de Henares, España

    ROR https://ror.org/04pmn0e78

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Journal:
Biociencias

ISSN: 2390-0512

Year of publication: 2019

Volume: 14

Issue: 2

Pages: 129-148

Type: Article

DOI: 10.18041/2390-0512/BIOCIENCIAS.2.6026 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

More publications in: Biociencias

Sustainable development goals

Abstract

Diabetes Mellitus is a chronic metabolism disorder that leads to an abnormal increase in plasma glucose levels, as a result of the unbalanced production of insulin and/or the insensitivity to the effect of this hormone on the transduction of signals from cell receptors. These metabolic changes are accompanied by changes in the metabolism of carbohydrates, lipids and proteins and this disorder could lead to deterioration of various organs such as blindness and is even involved in causes of death. Most of the complications of Type 2 Diabetes in patients are due to hyperglycemia as their main cause. One of the effective strategies for the management of type 2 diabetes is the inhibition of the hydrolysis of complex polysaccharides by pancreatic α-amylase and the limitation of glucose absorption by inhibiting the α-glucosidase enzyme. In this sense, a review of α-glucosidase, its mechanism of action has been carried out and a possible route of inhibition by natural flavonoids is presented.

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