Profiles of Mild Cognitive Impairment (MCI) in the Elderly

  1. Peraita Adrados, Herminia
  2. Chacón Gómez, José Carlos
  3. Díaz Mardomingo, Carmen
  4. Martínez Arias, María del Rosario
Journal:
The Spanish Journal of Psychology

ISSN: 1138-7416

Year of publication: 2015

Volume: 18

Type: Article

DOI: 10.1017/SJP.2015.96 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: The Spanish Journal of Psychology

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Abstract

We applied latent class analysis (LCA) to a set of neuropsychological data with the aim of corroborating the three cognitive profiles of mild cognitive impairment (MCI) described in the literature, namely: healthy, amnestic, non-amnestic, and multidomain. The ultimate purpose of the LCA was to try to find the underlying classification of MCI and related pathologies by means of the participants� response patterns, rather than on more classical psychometric criteria, such as the standard deviation of the mean. We computed 547 neuropsychological assessments derived from 223 participants who were assessed annually for three consecutive years. The battery included tests of memory, language, executive function, and praxis. The results obtained by means of LCA, with a four-group solution and using the 40th percentile as the criterion, confirm prior classifications obtained with more questionable psychometric criteria, while providing longitudinal data on the course of MCI and the stability of group assignment over time.

Bibliographic References

  • Alladi S., Arnold R., Mitchell J. Nestor P. J., & Hodges J. R. (2006). Mild cognitive impairment: Applicability of research criteria in a memory clinic and characterization of cognitive profile. Psychological Medicine, 36, 507–515. http://dx.doi.org/10.1017/S0033291705006744
  • Allegret M., Cubera-Borrós G., Vinyes-Junqué G., Espinosa A., Valero S., Hernández I., … Boada M. (2012). A two-year follow-up of cognitive deficits and brain perfusion in Mild Cognitive Impairment and mild Alzheimer’s disease. Journal of Alzheimer’s Disease, 30 109–120. http://dx.doi.org/10.3233/JAD-2012-111850
  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th Ed.). Arlington, VA: American Psychiatric Publishing.
  • Akaike H. (1973). Information theory and an extension of the maximum likelihood principle. In B. N. Petrov & F. Csaki (Eds.). Second international symposium on information theory (pp. 267–281). Budapest, Hungary: Academiai Kiado.
  • Artero S., Petersen R. C, Touchon J., & Ritchie K. (2006). Revised criteria for Mild Cognitive Impairment: Validation within a longitudinal population study. Dementia and Geriatric Cognitive Disorders, 22, 465–470. http://dx.doi.org/10.1159/000096287
  • Benedet M. J., & Alejandre M. A. (1998). Test de Aprendizaje Verbal España Complutense (TAVEC) [Verbal Learning Test Spain-Complutense]. Madrid, Spain: Publicaciones de Psicología Aplicada.
  • Bergman L. R., & Magnusson D. (1997). A person-oriented approach in research on developmental psychopathology. Development and Psychopathology, 9, 291–319. http://dx.doi.org/10.1017/S095457949700206X
  • Blessed G., Tomlinson B. E., & Roth M. (1968). The association between quantitative measures of dementia and of senile changes in the cerebral grey matter of older subjects. The British Journal of Psychiatry, 114, 797–811.
  • Bozdogan H. (1987). Model selection and Akaike’s information criterion (AIC): the general theory and its analytical extensions. Psychometrika, 52, 345–370. http://dx.doi.org/10.1007/BF02294361
  • Brandt J., Aretouli E., Neijstrom E., Samek J., Manning K., Albert M. S, & Bandeen-Roche K. (2009). Selectivity of executive function deficits in mild cognitive impairment. Neurology, 23, 607–618. http://dx.doi.org/10.1037/a0015851
  • Busse A., Hensel A., Gühne U., Angermeyer M. C., & Riedel-Heller S. G. (2006). Mild cognitive impairment. Long-term course of four clinical subtypes. Neurology, 67, 2176–2185. http://dx.doi.org/10.1212/01.wnl.0000249117.23318.e1
  • Caffara P., Ghetti C., Concari L., & Venneri A. (2008). Differential patterns of hypoperfusion in subtypes of mild cognitive impairment. The Open Neuroimaging Journal, 2, 20–28. http://dx.doi.org/10.2174/1874440000802010020
  • Cespón J., Galdo-Álvarez S., & Díaz F. (2013). Electrophysiological correlates of amnestic mild cognitive impairment in a Simon task. PLoS ONE, 8, e81506. http://dx.doi.org/10.1371/journal.pone.0081506
  • Cespón J., Galdo-Álvarez S., Pereiro A. X., & Díaz F. (2014). Differences between mild cognitive impairment subtypes as indicated by even-related potential correlates of cognitive and motor processes in a Simon task. Journal of Alzheimer’s Disease, 43, 631–647. http://dx.doi.org/10.3233/JAD-132774
  • Clément F., & Belleville S. (2010). Compensation and disease severity on the memory-related activations in mild cognitive impairment. Biological Psychiatry, 68, 894–902. http://dx.doi.org/10.1016/j.biopsych.2010.02.004
  • Cohen J. (1960). A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37–46. http://dx.doi.org/10.1177/001316446002000104
  • Collins L. M., & Lanza S. T. (2010). Latent class and latent transition analysis for the social, behavioral, and health sciences. New York, NY: Wiley.
  • Comijs H. C., Dik M. G., Deeg D. J. H., & Jonker C. (2004). The course of cognitive decline in older persons: Results from the longitudinal aging study Amsterdam. Dementia and Geriatric Cognitive Disorders, 17, 136–142. http://dx.doi.org/10.1159/000076346
  • Díaz-Mardomingo M. C., Chacón J., Martínez M. R., & Peraita H. (2012). Dimensiones cognitivas de una batería de test neuropsicológicos obtenidas mediante un análisis factorial. Aplicación a un estudio longitudinal sobre deterioro cognitivo ligero [Cognitive dimensions of a neuropsychological battery obtained by factorial analysis. Application to a longitudinal study on MCI]. Psicothema, 24, 587–593.
  • Díaz C., & Peraita H. (2008). Detección precoz del deterioro cognitivo ligero de la tercera edad [Early detection of MCI in the aging]. Psicothema, 20, 438–444.
  • Díaz C., García S., & Peraita H. (2010). Detección precoz del DCL y conversión a la enfermedad de Alzheimer: Un estudio longitudinal de casos [Early detection of MCI and conversion to AD. A longitudinal study base on individual cases] Psicogeriatría. 2, 105–111.
  • Dubois B., Feldman H. H., Jacova C., Cummings J. L., Dekosky S. T., Barberger-Gateau, … de Souza L. C. (2010). Revising the definition of Alzheimer’s disease: A new lexicon. Lancet Neurology, 9, 1118–1127. http://dx. doi.org/10.1016/S1474-4422(10)70223-4
  • Espinosa A., Alegret M., Valero S., Vinyes-Junqué G., Hernández I., Mauleón A., … Boada M. (2013). A longitudinal follow-up of 550 Mild Cognitive Impairment patients: Evidence for large conversion to dementia rates and detection of major risk factors involved. Journal Alzheimers Disorders, 34, 769–780. http://dx.doi. org/10.3233/JAD-122002
  • Ganguli M., Dodge H. H., Shen C. T., & DeKosky S. (2004). Mild cognitive impairment, amnesic type: An epidemiologic study. Neurology, 63, 115–121.
  • Ganguli M., Snitz B. E., Lee C-W., Vanderbilt J., Saxton J. A., & Chang C-C. H. (2010). Age and education effects and norms on a cognitive test battery from a population-based cohort: The Monongahela – Youghiogheny Healthy Aging Team (MYHAT). Aging Mental Health, 14, 100–107. http://dx.doi.org/10.1080/13607860903071014
  • Ganguli M., Snitz B. E., Saxton J. A., Chang C. C. H., Lee C-W., Vander Bilt J., … Petersen R. C. (2011). Outcomes of mild cognitive impairment by definition: A population study. Archives of Neurology, 68, 761–767. http://dx.doi.org/10.1001/archneurol.2011.101
  • Lanza S. T., & Rhoades B. L. (2013). Latent class analysis: An alternative perspective on subgroup analysis in prevention and treatment. Prevention Science, 14, 157–168. http://dx.doi.org/10.1007/s11121-011-0201-1
  • Lanza S. T., Collins L. M., Lemmon D. R., & Schafer J. L. (2007). PROC LCA: A SAS procedure for latent class analysis. Structural Equation Modeling, 14, 671–694. http://dx.doi.org/10.1080/10705510701575602
  • Lanza S. T., Lemmon D., Dziak J. J., Huang L., Schafer J. L., & Collins L. M. (2010). Proc LCA & Proc LTA Users' Guide Version 1.2.5 Beta. Pennsylvania, PA: The Methodology Center, The Pennsylvania State University.
  • Lobo A., Ezquerra J., Gómez F., Sala J. M., & Seva A. (1979). El Mini-Examen Cognoscitivo. Un test sencillo, práctico, para detectar alteraciones intelectivas en pacientes médicos [The Cognitive MMSE. A simple, functional test to detect intelectual troubles in clinical patients]. Actas Luso Españolas de Neurología Psiquiatría y Ciencias Afines, 3, 189–202.
  • Loewenstein D. A., Acevedo A., Small B. J., Agron J., Croco E., & Duara R. (2009). Stability of different subtypes of mild cognitive impairment among the elderly over a 2to 3-year follow-up period. Dementia and Geriatric Cognitive Disorders, 27, 418–423. http://dx.doi.org/10.1159/000211803
  • Manly J. J., Tang M. X., Schupf N., Stern Y., Vonsattel J. P, & Mayeux R. (2008). Frequency and course of mild cognitive impairment in a multiethnic community. Annals of Neurology, 63, 494–506. http://dx.doi.org/10.1002/ana.21326
  • Migliacci M. L., Scharovsky D., & Gonorazky S. E. (2009). Deterioro cognitivo leve: Características neuropsicológicas de los distintos subtipos [Mild cognitive impairment: Neuropsychological caracteristic of different subtypes]. Revista de Neurología, 48, 237–241.
  • Mulet B., Sánchez-Casas R., Arrufat M. T., Figuera L., Labad A., & Rosich M. (2005). Deterioro cognitivo ligero anterior a la enfermedad de Alzheimer: Tipologías y evolución [Mild cognitive impairment previous AD: Typologies and evolution]. Psicothema, 17, 250–256.
  • Mungas D., Beckett L., Harvey D., Tomaszewski F. S., Reed B., Carmichael O., … DeCarli C. (2010). Heterogeneity of cognitive trajectories in diverse older persons. Psychology and Aging, 25, 606–619. http://dx.doi.org/10.1037/a0019502
  • Nordlund A., Rolstad S., Klang O., Edman A., Hansen S., & Wallin A. (2010). Two-year outcome of MCI subtypes and aetiologies in the Göteborg MCI study. Journal of Neurology Neurosurgery and Psychiatry, 81, 541–546. http://dx.doi.org/10.1136/jnnp.2008.171066
  • Peña-Casanova J. (1991). Programa integrado de exploración neuropsicológica ¨Test Barcelona. Normalidad, semiología y patología neuropsicológica [Integrated program for neuropsychological examination. Barcelona Test. Normality, semiology and and neuropsychogical pathologies]. Barcelona, Spain: Masson.
  • Peña-Casanova J., Blesa R., Aguilar M., GramuntFombuena N., Gómez-Ansón B., Oliva R., … Sol J. M. (2009). Spanish multicenter normative studies (NEURONORMA Proyect): Methods and simple characteristics. Archives Clinical of Neuropsychiatry, 24, 307–319. http://dx.doi.org/10.1093/arclin/acp027
  • Peraita H., García-Herranz S., & Díaz-Mardomingo C. (2011). Evolution of specific cognitive subprofiles of mild cognitive impairment in a three-year longitudinal study. Current Aging Science, 4, 171–182. http://dx.doi.org/10.2174/1874609811104020171
  • Peraita H., González-Labra M. J., Sánchez-Bernardos M. L., & Galeote M. (2000). Batería de Evaluación del deterioro de la Memoria Semántica en EA (EMSDA) [Semantic Memory Evaluation Battery in AD]. Psicothema, 12, 192–200.
  • Petersen R. C, Smith G. E., Waring S. C., Ivnik R. J., Tangalos E. G., & Kokmen E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56, 303–308. http://dx.doi.org/10.1001/archneur.56.3.303
  • Petersen R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194. http://dx.doi.org/10.1111/j.1365-2796.2004.01388.x
  • Petersen R. C., & Negash S. (2008). Mild cognitive impairment: An overview. CNS Spectrums, 131(1), 45–43.
  • Petersen R. C., Roberts R. O., Knopman D. S., Geda Y. E., Cha R. H., Pankratz V. S., … Rocca W. A. (2010). Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology, 75, 889–897. http://dx.doi.org/10.1212/WNL.0b013e3181f11d85
  • Petersen R. C., Doody R., Kurz A., Mohs R. C., Morris J. C., Rabins P. V., … Winblad B. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58, 1985–1992. http://dx.doi.org/10.1001/archneur.58.12.1985
  • Rey A. (2003). Rey. Test de copia y de reproducción de memoria de figuras geométricas complejas [Rey. Copy and reproduction test of memory geometric complex patterns]. Madrid, Spain: TEA.
  • Reitan R. M., & Wolfson D. (1993). The Halstead-Reitan Neuropsychological Test Battery: Theory and clinical interpretation (2nd Ed.). Tucson, AZ: Neuropsychology Press.
  • Ritchie K., Artero S., & Touchon J. (2001). Classification criteria for mild cognitive impairment: A population-based validation study. Neurology, 56, 37–42. http://dx.doi. org/10.1212/WNL.56.1.37
  • Ritchie K. (2004). Mild cognitive impairment: An epidemiological perspective. Dialogues in Clinical Neuroscience, 6, 401–408.
  • Ruscio J., & Ruscio A. M. (2008). Categories and Dimensions advancing psychological science through the study of latent structure. Current Directions in Psychological Science, 17, 203–207.
  • Saxton J., Snitz B. E., López O. L., Ives D. G., Dunn L. O., Fitzpatrick A., … DeKosky S. T. (2009). Functional and cognitive criteria procedure different rates of MCI and conversion to dementia. Journal Neurol Neurosurg Psychiatry, 80, 737–743.
  • Schwarz G. (1978). Estimating the dimension of a model. The Annals of Statistics, 6, 461–464. http://dx.doi.org/10.1214/aos/1176344136
  • Sclove S. L. (1987). Application of model-selection criteria to some problems in multivariate analysis. Psychometrika, 52, 333–343. http://dx.doi.org/10.1007/BF02294360
  • Umesh U. N., Peterson R. A., & Sauber M. H. (1989). Inter judge agreement and the maximum value of kappa. Educational and Psychological Measurement, 49, 835–850. http://dx.doi.org/10.1177/001316448904900407
  • Yesavage J. A., Brink T. L., Rose T. L., Lum O., Huang V., Adey M., & Leirer V. O. (1983). Development and validation of a geriatric depression scale: A preliminary report. Journal of Psychiatric Research, 7, 37–49. http://dx.doi. org/10.1016/0022-3956(82)90033-4
  • Zacks R. T., Hasher L., & Li K. Z. H. (2000). Human memory. In F. I. M. Craik, T. A. Salthouse, (Ed.), The handbook of aging and cognition (2nd Ed). (pp. 293–357). Mahwah, N.J: Lawrence Erlbaum.