Cognitive function in normal aging and in older adults with mild cognitive impairment

  1. Ballesteros Jiménez, Soledad
  2. Mayas Arellano, Julia
  3. Reales Avilés, José Manuel
Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 2013

Volumen: 25

Número: 1

Páginas: 18-24

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Antecedentes: en este estudio investigamos los efectos del envejecimiento sano y patológico (déficit cognitivo leve, DCL) en varias funciones cognitivas (control ejecutivo, velocidad de procesamiento y memoria implícita). Método: veinte adultos jóvenes, 20 mayores sanos y 20 mayores DCL realizaron una serie de tareas cognitivas bajo condiciones controladas. Estas tareas fueron tiempo de reacción simple y de elección, el Test Wisconsin y una tarea de memoria implícita para objetos atendidos y no atendidos durante la codificación. Resultados: el grupo DCL mostró declives pronunciados en las tareas de velocidad de procesamiento y de control ejecutivo. Además, los jóvenes y los mayores sanos mostraron priming para los objetos atendidos durante la codificación estimular, pero no los mayores con DCL. Conclusiones: en este último grupo, la falta de priming de repetición para objetos atendidos en la tarea de memoria implícita fueron similares a los de los enfermos de Alzheimer (EA) y sugieren la existencia de un déficit temprano de la atención selectiva en mayores DCL, lo que podría ser un marcador del envejecimiento patológico.

Referencias bibliográficas

  • Baltes, P.B., & Lindenberger, U. (1997). Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window at the study of cognitive aging? Psychology and Aging, 12, 12-21.
  • Ballesteros, S., Peter, C., Waterworth, E.L., & Waterworth, J.A. (2012). The role of ICT and networking in healthy aging. The 5th ACM International Conference on Pervasive Technologies Related to Assistive Environments: PETRA 2012 [CDROM]. New York: ACM, 2012.
  • Ballesteros, S., & Reales, J.M. (2004). Intact haptic priming in normal aging and Alzheimer's disease: Evidence for dissociable memory systems. Neuropsychologia, 44, 1063-1070.
  • Ballesteros, S., Reales, J.M., García, E., & Carrasco, M. (2006). Selective attention effects on implicit and explicit memory for familiar objects at different delay conditions. Psicothema, 18, 96-107.
  • Ballesteros, S., Reales, J.M., & Mayas, J. (2007). Picture priming in aging and dementia. Psicothema, 19, 239-244.
  • Ballesteros, S., Reales, J.M, Mayas, J., & Heller, M.A. (2008). Selective attention modulates visual and haptic repetition priming: Effects on aging and Alzheimer's disease. Experimental Brain Research, 189, 473-483.
  • Basak, Ch., Boot, W.R., Voss, M.W., & Kramer, A.F. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging, 23, 765-777.
  • Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D. A., Beckett, L.A., et al. (2002). Natural history of mild cognitive impairment in older persons. Neurology, 59, 198-205.
  • Borkowska, A., Drozdz, W., Jurkowski, P., & Rybakowski, J.K. (2009). The Wisconsin Card Sorting Test and the N-back test in mild cognitive impairment and elderly depression. World Journal of Biological Psychiatry, 10, 870-876.
  • Burns, A., & Zaudig, M. (2002). Mild cognitive impairment in older people. Lancet, 360, 1963-1965.
  • Crabb, B.T., & Dark, V.J. (1999). Perceptual implicit memory requires attentional encoding. Memory and Cognition 27, 267-275.
  • Craik, F.I.M., Govoni, R., Naveh-Benjamin, M., & Anderson, N.D. (1996). The effects of divided attention on encoding and retrieval processes in human memory. Journal of Experimental Psychology: General, 125, 159-180.
  • Craik, F.I.M., & Salthouse, T.A. (Eds.) (2000). Handbook of aging and cognition (2nd ed.). Hillsdale, NJ: Erlbaum.
  • Dannhauser, T.M., Shergill, S.S., Stevens, T., Lee, L., Seal, M., Walker, R.W.H., & Walker, Z. (2008). An fMRI study of verbal episodic memory encoding in amnestic mild cognitive impairment. Cortex, 44, 869-880.
  • Dannhauser, T.M, Walker, Z., Stevens, T., Lee, L., Seal, M., & Shergill, S.S. (2005). The functional anatomy of divided attention in amnestic mild cognitive impairment. Brain, 128, 1418-1427.
  • Demakis, G.J. (2003). A meta-analytic review of the sensitivity of the Wisconsin Card Sorting Test to frontal and lateralized frontal brain damage. Neuropsychology, 17, 255-264.
  • Duverne, S., Habibi, A., & Rugg, M.D. (2008). Regional specificity of age effects on the neural correlates of episodic retrieval. Neurobiology of Aging, 29, 1902-1916.
  • Eckert, M.A. (2011). Slowing down: Age-related neurobiological predictors of processing speed. Frontiers in Neuroscience, 5, 1-13.
  • Eger, E., Henson, R.N.A., Driver, J., & Dolan, J. (2004). BOLD repetition decreases in object-responsive ventral visual areas depends on spatial attention. Journal of Neurophysiology, 92, 1241-1247.
  • Erickson, K.I., & Kramer, A.F. (2009). Aerobic exercise effects on cognitive and neural plasticity. British Journal of Sport Medicine, 43, 22-24.
  • Fleischman, D.A. (2007). Repetition priming in aging and AD: An integrative review and future directions. Cortex, 43, 889-897.
  • Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R.C., Ritchie, K., et al., (2006). Mild cognitive impairment. Lancet, 367, 1262-1270.
  • Gunning-Dixon, F.M., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: A prospective MRI study. Neuropsychologia, 41, 1929-1941.
  • Gutchess, A.H., & Park, D. (2009). Effects of ageing on associative memory for related and unrelated pictures. European Journal of Cognitive Psychology, 21, 235-254.
  • Heaton, R.K. (1981). Wisconsin Card Sorting test manual. Odessa, Fl: Psychological Assessment Resources.
  • Henson, R.N.A. (2003). Neuroimaging studies of priming. Progress in Neurobiology, 70, 53-81.
  • Hertzog, C., Kramer, A.F., Wilson, R.S., & Lindenberger, U. (2009). Enrichment effects on adult cognitive development. Psychological Science in the Public Interest, 9, 1-65.
  • MacDonald, P.A., & MacLeod, C.M. (1998). The influence of attention at encoding on direct and indirect remembering. Acta Psychologica, 98, 291-310.
  • Milner, B. (1963). Effects of different brain lesions on card sorting. Archives of Neurology, 9, 90-100.
  • Morris, J.C., Storandt, M., Miller, McKeel, D.W., Price, J.L., et al. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Archives of Neurology, 58, 397-405.
  • Murray, S.O., & Wojciulik, E. (2004). Attention increases neural selectivity in the human lateral occipital cortex. Nature Neuroscience, 7, 70-74.
  • Nordahl, C.W., Ranganath, C., Yonelinas, A.P., DeCarli, C., Reed, B.R., & Jagust, W.J. (2005). Different mechanisms of episodic memory failure in mild cognitive impairment. Neuropsychologia, 43(11), 1688-1697.
  • Osorio, A., Ballesteros, S., Fay, S., & Pouthas, V. (2009). The effect of age on Word-stem cued recall: A behavioral and electrophysiological study. Brain Research, 1289, 56-68.
  • Osorio, A., Fay, S., Pouthas, V., & Ballesteros, S. (2010). Ageing affects brain activity in highly educated older adults: An ERP study using a word-stem priming task. Cortex, 46, 522-534.
  • Parasuraman, R., & Haxby, J.V. (1993). Attention and brain functions in Alzheimer's disease. A review. Neuropsychology, 7, 243-273.
  • Peña-Casanova, J. (1991). Programa Integrado de Exploración Neuropsicológica (Test Barcelona). Normalidad, semiología y patología neuropsicológica. Barcelona: Masson.
  • Peterson, R.C. (2011). Mild cognitive impairment. The New England Journal of Medicine, 364, 2227-2234.
  • Peterson, R.C., Stevens, J.C., Ganguli, M., Tangalos, E.G., Cummings, J.L., & Dekosky, S.T. (2001). Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133-1142.
  • Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D., et al. (2005). Regional brain changes in healthy aging adults: General trends, individual differences and modifiers. Cerebral Cortex, 15, 1676-1689.
  • Raz, N., Rodrigue, K.M., & Acker, J.D. (2003). Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions. Behavioral Neuroscience, 117, 1169-1180.
  • Reuter-Lorenz, P.A., & Lustig, C. (2005). Brain aging: Reorganizing discoveries about the aging mind. Current Opinions in Neurobiology, 15, 245-251.
  • Rock, I., & Gutman, D. (1981). The effect of inattention on form perception. Journal of Experimental Psychology: Human, Perception and Performance, 9, 275-285.
  • Salthouse, T.A. (1996). The processing-speed theory of adult age differences in cognition. Psychological Review, 103, 403-428.
  • Salthouse, T.A., & Ferrer-Caja, E. (2003). What needs to be explained to account for age-related effects on multiple cognitive variables? Psychology and Aging, 18, 91-110.
  • Schacter, D.L., Wig, G.S., & Stevens, W.D. (2007). Reductions in cortical activity during priming. Current Opinions in Neurobiology, 17, 171-176.
  • Sebastián, M., & Ballesteros, S. (2012). Effects of normal aging on event- related potentials and oscillatory brain activity during a haptic repetition priming task. NeuroImage, 60, 7-20.
  • Sebastián, M., Reales, J.M., & Ballesteros, S. (2011). Aging affects event-related potentials and brain oscillations: A behavioural and electrophysiological study using a haptic recognition memory task. Neuropsychologia, 49, 3967-3980.
  • Sliwinski, M., Lipton, R.B., Buschke, H., & Stewart, W. (1996). The effects of preclinical dementia on estimates of normal cognitive functioning in aging. Journal of Gerontology, 51B, 217-225.
  • Snodgrass, J.G., & Vanderwart, M. (1980). A standardized set of 260 pictures: Norms for name agreement, image agreement, familiarity, and visual complexity. Journal of Experimental Psychology: Human Learning and Memory, 6, 174-215.
  • Vasquez, B.P., Buck, B.H., Black, S.E., Leibowitch, F. S., Lobaugh, N.J., et al. (2011). Visual attention deficits in Alzheimer's disease: Relationship to HMPAO SPECT cortical hypoperfusion. Neuropsychologia, 49, 1741-1750.
  • Vuilleumier, P., George, N., Lister, V., Armony, J., & Driver, J. (2005). Effects of perceived mutual gaze on face judgments and face recognition memory. Visual Cognition, 12, 85-101.
  • Waterworth, J., Ballesteros, S., & Peter, C. (2009). User-sensitive home-based systems for successful ageing. Proceedings of the 2nd International Conference on Human system Interaction. Catania. Italy, May 2009. IEEE Computer Society.
Fuente de los datos: Dialnet