El ritmo y la tasa de habla como ayuda diagnóstica en síndromes neurodegenerativos de los lóbulos fronto-temporales

  1. Wendy Elvira García 1
  2. Victoria Marrero Aguiar 1
  1. 1 Universidad Nacional de Educación a Distancia
    info

    Universidad Nacional de Educación a Distancia

    Madrid, España

    ROR https://ror.org/02msb5n36

Revista:
Loquens : revista española de ciencias del habla

ISSN: 2386-2637

Año de publicación: 2020

Volumen: 7

Número: 1

Páginas: 2

Tipo: Artículo

DOI: 10.3989/LOQUENS.2020.068 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Loquens : revista española de ciencias del habla

Resumen

Temporal variables have proven to be an effective tool to characterize speech in neurodegenerative diseases and primary progressive aphasia variants, but the evidence available so far is essentially limited to English. This article analyses, by means of a small sample of seven patient groups and a control group (total n = 34; control group = 6; progressive primary aphasia, en three variants = 15; fronto-temporal dementia in two variants = 9; supranuclear progressive palsy = 3; cortico-basal syndrome = 2), the temporal parameters of speech rate, vowel duration, consonant duration, and nine rhythmic metrics (%V, %C, ΔV, ΔC, VarcoV, VarcoC, rPVI-V, rPVI-C, nPVI-V). The results indicate that speech rate is slower in patients with primary progressive non-fluent aphasia (APPnf), amyotrophic lateral sclerosis (ALS), or corticobasal syndrome (CBS) than in controls. These three clinical groups, as well as those suffering from progressive supranuclear palsy (PSP), have longer segmental durations, especially in consonants. Among the rhythm metrics, %C, ΔV and rPVI-C also allow to differentiate between groups, specifically, between control and APPlog, ELA-DFT y SCB.

Referencias bibliográficas

  • Allegri, R. F., Villavicencio, A. F., Taragano, F. E., Rymberg, S., Mangone, C. A., y Baumann, D. (1997). Spanish Boston naming test norms. The Clinical Neuropsychologist, 11(4), 416-420. https://doi.org/10.1080/13854049708400471
  • Ash, S., Evans, E., O'Shea, J., Powers, J., Boller, A., Weinberg, D., ... y Grossman, M. (2013). Differentiating primary progressive aphasias in a brief sample of connected speech. Neurology, 81(4), 329-336. https://doi.org/10.1212/WNL.0b013e31829c5d0e PMid:23794681 PMCid:PMC3772830
  • Ash, S., McMillan, C., Gunawardena, D., Avants, B., Morgan, B., Khan, A., ... y Grossman, M. (2010). Speech errors in progressive non-fluent aphasia. Brain and Language, 113(1), 13-20. https://doi.org/10.1016/j.bandl.2009.12.001 PMid:20074786 PMCid:PMC2839014
  • Bak, T. H. y Abrahams, S. (2016). The FTD-ALS spectrum. En B. C. Dickerson (Ed.), Hodges' Frontotemporal Dementia. 2ª edic. (pp. 68-81). Cambridge: Cambridge University Press. https://doi.org/10.1017/CBO9781316091586.009
  • Ballard, K. J., Savage, S., Leyton, C. E., Vogel, A. P., Hornberger, M. y Hodges, J. R. (2014). Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production. PLoS ONE, 9(2). https://doi.org/10.1371/journal.pone.0089864 PMid:24587083 PMCid:PMC3938536
  • Bates, D. M., Mächler, M. y Bolker, B. (2012). lme4: Linear Mixed-Effects Models Using S4 Classes. R package version 0.999999-0. http://lme4.r-forge.r-project.org/
  • Boersma, Paul y Weenink, David (2020). Praat: Doing Phonetics by Computer (programa informático). Version 6.1.14 http://www.praat.org/
  • Benedet, M., Patterson, K., Gomez-Pastor, I. y García de la Rocha, M. L. (2006). 'Non-semantic' aspects of language in semantic dementia: As normal as they're said to be? Neurocase, 12(1), 15-26. https://doi.org/10.1080/13554790500446868 PMid:16517512
  • Canellada, M. J. y Madsen, J. K. (1987). Pronunciación del español. Lengua hablada y literaria. Madrid: Castalia.
  • Carmona-Abellán, M. M., Luquin, M. R., Lamet, I., Pujol Giménez, N., Esteve-Belloch, P. y Rivero, M. (2015). Perfil neuropsicológico de la degeneración lobar frontotemporal. Anales del Sistema Sanitario de Navarra, 38(1), 79-92. https://doi.org/10.4321/S1137-66272015000100009 PMid:25963461
  • Charles, D., Olm, C., Powers, J., Ash, S., Irwin, D. J., McMillan, C. T, Rascovsky, K. y Grossman, M. (2014). Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia. Journal of Neurology, Neurosurgery and Psychiatry, 85(3), 249-256. https://doi.org/10.1136/jnnp-2013-305749 PMid:24039027 PMCid:PMC3925677
  • Code, C., Ball, M., Tree, J. y Dawe, K. (2013). The effects of initiation, termination and inhibition impairments on speech rate in a case of progressive nonfluent aphasia with progressive apraxia of speech with frontotemporal degeneration. Journal of Neurolinguistics, 26(6), 602-618. https://doi.org/10.1016/j.jneuroling.2013.04.003
  • Cordella, C., Dickerson, B. C., Quimby, M., Yunusova, Y. y Green, J. R. (2017). Slowed articulation rate is a sensitive diagnostic marker for identifying non-fluent primary progressive aphasia. Aphasiology, 31(2), 241-260. https://doi.org/10.1080/02687038.2016.1191054 PMid:28757671 PMCid:PMC5531197
  • Cordella, C., Quimby, M., Touroutoglou, A., Brickhouse, M., Dickerson, B. C. y Green, J. R. (2019). Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia. Neurology, 92(17), e1992-e2004. https://doi.org/10.1212/WNL.0000000000007367 PMid:30944238 PMCid:PMC6511075
  • Dellwo, V. y Wagner, P. (2003). Relationships between rhythm and speech rate. En M. J. Solé, D. Recasens y J. Romero (Eds.), Proceedings of the 15th ICPhS (pp. 471-474). Barcelona: Universidad de Barcelona.
  • Duffy, J. R., Hanley, H., Utianski, R., Clark, H., Strand, E., Josephs, K. A. y Whitwell, J. L. (2017). Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia. Brain and Language, 168, 84-94. https://doi.org/10.1016/j.bandl.2017.01.012 PMid:28187331 PMCid:PMC5366265
  • Duffy, J. R., Strand, E. A., Clark, H., Machulda, M., Whitwell, J. L. y Josephs, K. A. (2015). Primary progressive apraxia of speech: Clinical features and acoustic and neurologic correlates. American Journal of Speech-Language Pathology, 24(2), 88-100. https://doi.org/10.1044/2015_AJSLP-14-0174 PMid:25654422 PMCid:PMC4451786
  • Enderby, P. (1993). Speech and language therapy for aphasia. Current Opinion in Neurology, 6(5), 761-764. https://doi.org/10.1097/00019052-199310000-00014 PMid:7507396
  • Fraser, K. C., Meltzer, J. A., Graham, N. L., Leonard, C., Hirst, G., Black, S. E. y Rochon, E. (2014). Automated classification of primary progressive aphasia subtypes from narrative speech transcripts. Cortex, 55, 43-60. https://doi.org/10.1016/j.cortex.2012.12.006 PMid:23332818
  • Geranmayeh, F., Chau, T. W., Wise, R. J., Leech, R. y Hampshire, A. (2017). Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke. Brain, 140(7), 1947-1958. https://doi.org/10.1093/brain/awx134 PMid:29177494 PMCid:PMC5903407
  • Goodglass, H., Kaplan, E. y Barresi, B. (2001). BDAE-3: Boston Diagnostic Aphasia Examination-Third Edition. Philadelphia, PA: Lippincott Williams & Wilkins.
  • Gorno-Tempini, M. L. y Santos Santos, M. Á. (2015). Primary progressive aphasia. En A. W. Toga (Ed.), Brain Mapping (pp. 653-663). Waltham: Academic Press. https://doi.org/10.1016/B978-0-12-397025-1.00074-9
  • Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., ... y Manes, F. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006-1014. https://doi.org/10.1212/WNL.0b013e31821103e6 PMid:21325651 PMCid:PMC3059138
  • Gorno-Tempini, M. L., Murray, R. C., Rankin, K. P., Weiner, M. W. y Miller, B. L. (2004). Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report. Neurocase, 10(6), 426-436. https://doi.org/10.1080/13554790490894011 PMid:15788282 PMCid:PMC2365737
  • Grabe, E. y Low, E. L. (2002). Durational variability in speech and the rhythm class hypothesis. Papers in Laboratory Phonology, 7, 515-546. https://doi.org/10.1515/9783110197105.515
  • Gross, R. G., Ash, S., McMillan, C. T., Gunawardena, D., Powers, C., Libon, D. J., ... y Grossman, M. (2010). Impaired information integration contributes to communication difficulty in corticobasal syndrome. Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology, 23(1), 1. https://doi.org/10.1097/WNN.0b013e3181c5e2f8 PMid:20299856 PMCid:PMC2930985
  • Grossman, M., Powers, J., Ash, S., McMillan, C., Burkholder, L., Irwin, D. y Trojanowski, J. Q. (2013). Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology. Brain and Language, 127(2), 106-120. https://doi.org/10.1016/j.bandl.2012.10.005 PMid:23218686 PMCid:PMC3610841
  • Gunawardena, D., Ash, S., McMillan, C., Avants, B., Gee, J. y Grossman, M. (2010). Why are patients with progressive nonfluent aphasia nonfluent? Neurology, 75(7), 588-594. https://doi.org/10.1212/WNL.0b013e3181ed9c7d PMid:20713947 PMCid:PMC2931767
  • Hartelius, L., Svensson, P. y Bubach, A. (1993). Clinical assessment of dysarthria: Performance on a dysarthria test by normal adult subjects, and by individuals with Parkinson's disease or with multiple sclerosis. Scandinavian Journal of Logopedics and Phoniatrics, 18(4), 131-141. https://doi.org/10.3109/14015439309101359
  • Hernández-Sacristán, C. y Rosell-Clari, V. (2009). Syntax and conversation in aphasia. A strategic restrictive use of Spanish and Catalan connector QUE by aphasic speakers. Clinical Linguistics & Phonetics, 23(10), 717-741. https://doi.org/10.3109/02699200903063053 PMid:19883183
  • Hixon, T. J. y Hardy, J. C. (1964). Restricted motility of the speech articulators in cerebral palsy. Journal of Speech and Hearing Disorders, 29(3), 293-306. https://doi.org/10.1044/jshd.2903.293 PMid:14210034
  • Hothorn, T., Bretz, F., Westfall, P., Heiberger, R. M., Schuetzenmeister, A., Scheibe, S. y Hothorn, M. T. (2016). Package 'Multcomp'. Simultaneous Inference in General Parametric Models. Paquete de R.
  • Josephs, K. A. y Duffy, J. R. (2008). Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy. Current Opinion in Neurology, 21(6), 688-692. http://dx.doi.org/10.1097/WCO.0b013e3283168ddd https://doi.org/10.1097/WCO.0b013e3283168ddd PMid:18989114
  • Kaplan, E., Goodglass, H. y Weintraub, S. (1983). The Boston Naming Test. Philadelphia: Lea and Febiger.
  • Kent, R. D., Kent, J. F. y Rosenbek, J. C. (1987). Maximum performance tests of speech production. Journal of Speech and Hearing Disorders, 52(4), 367-387. https://doi.org/10.1044/jshd.5204.367 PMid:3312817
  • Kent, R. D., Weismer, G., Kent, J. F., Vorperian, H. K. y Duffy, J. R. (1999). Acoustic studies of dysarthric speech: Methods, progress, and potential. Journal of Communication Disorders, 32(3), 141-186. https://doi.org/10.1016/S0021-9924(99)00004-0
  • Kertesz, A. (2007). Western Aphasia Battery: Revised. New Jersey: Pearson. https://doi.org/10.1037/t15168-000
  • Lillo, P. y Hodges, J. R. (2009). Frontotemporal dementia and motor neuron disease: overlapping clinic-pathological disorders. Journal of Clinical Neuroscience, 16, 1131-1135 https://doi.org/10.1016/j.jocn.2009.03.005 PMid:19556136
  • Llisterri, J., Machuca, M. J., Ríos, A. y Schwab, S. (2014). El acento léxico en contexto: datos acústicos. En Y. Congosto, M. L. Montero y A. Salvador (Eds.), Fonética experimental, educación superior e investigación (Vol. 1, pp. 357-376). Madrid: Arco/Libros
  • Mairano, P. y Romano, A. (2010). Un confronto tra diverse metriche ritmiche usando Correlatore 1.0. La dimensione temporale del parlato, 427, 44-45.
  • Marshall, C. R., Hardy, C. J., Volkmer, A., Russell, L. L., Bond, R. L., Fletcher, P. D., ... y Fox, N. C. (2018). Primary progressive aphasia: a clinical approach. Journal of Neurology, 265(6), 1474-1490. https://doi.org/10.1007/s00415-018-8762-6 PMid:29392464 PMCid:PMC5990560
  • Martínez-Ferreiro, S., Vares, E., Rosell, V. y Bastiaanse, R. (2017). Quantifying connected discourse in Spanish-speaking individuals with aphasia: The case of mixed aphasias. Journal of Neurolinguistics, 44, 38-53. https://doi.org/10.1016/j.jneuroling.2017.03.001
  • Mathew, R., Bak, T. H. y Hodges, J. R. (2012). Diagnostic criteria for corticobasal syndrome: a comparative study. Journal of Neurology, Neurosurgery and Psychiatry, 83(4), 405-410. https://doi.org/10.1136/jnnp-2011-300875 PMid:22019546
  • Meilán, J. J. G., Martínez-Sánchez, F., Carro, J., López, D. E., Millian-Morell, L. y Arana, J. M. (2014). Speech in Alzheimer's disease: Can temporal and acoustic parameters discriminate dementia? Dementia and Geriatric Cognitive Disorders, 37(5-6), 327-334. https://doi.org/10.1159/000356726 PMid:24481220
  • Meilán, J. J., Martínez-Sánchez, F., Carro, J., Sánchez, J. A. y Pérez, E. (2012). Acoustic markers associated with impairment in language processing in Alzheimer's disease. The Spanish Journal of Psychology, 15(2), 487-494. https://doi.org/10.5209/rev_SJOP.2012.v15.n2.38859 PMid:22774422
  • Monroy Casas, R. (2005). Aspectos fonéticos de las vocales españolas. LibrosEnRed: https://www.librosenred.com/
  • Murley, A. G., Coyle-Gilchrist, I., Rouse, M. A., Jones, P. S., Li, W., Wiggins, J., ... y Patterson, K. (2020). Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes. Brain, 143(5), 1555-1571. https://doi.org/10.1093/brain/awaa097 PMid:32438414 PMCid:PMC7241953
  • Navarro Tomás, T. (1918). Manual de pronunciación española. Madrid: CSIC.
  • Ogar, J. M., Dronkers, N. F., Brambati, S. M., Miller, B. L. y Gorno-Tempini, M. L. (2007). Progressive nonfluent aphasia and its characteristic motor speech deficits. Alzheimer Disease and Associated Disorders, 21(4), 23-30. https://doi.org/10.1097/WAD.0b013e31815d19fe PMid:18090419
  • Ozsancak, C., Auzou, P., Jan, M., Defebvre, L., Derambure, P. y Destee, A. (2006). The place of perceptual analysis of dysarthria in the differential diagnosis of corticobasal degeneration and Parkinson's disease. Journal of Neurology, 253(1), 92-97. https://doi.org/10.1007/s00415-005-0932-7 PMid:16096817
  • Pastoriza-Domínguez, P., Diéguez-Vide, F. Gómez-Ruiz, M. I., Bello-López, J. y Águila-Rivera, A. (2017). (Dis)fluency markers in dementia: how much can errors tell us? Frontiers in Human Neuroscience, 11 (Conference Abstract: Academy of Aphasia 55th Annual Meeting). https://doi.org/10.3389/conf.fnhum.2017.223.00115
  • Patterson, K., Nestor, P. J. y Rogers, T. T. (2007). Where do you know what you know? The representation of semantic knowledge in the human brain. Nature Reviews Neuroscience, 8(12), 976-987. https://doi.org/10.1038/nrn2277 PMid:18026167
  • Peña-Casanova, J., Quiñones-Úbeda, S., Gramunt-Fombuena, N., Aguilar, M., Casas, L., Molinuevo, J. L., ... y Martínez-Parra, C. (2009). Spanish Multicenter Normative Studies (NEURONORMA Project): norms for Boston naming test and token test. Archives of Clinical Neuropsychology, 24(4), 343-354. https://doi.org/10.1093/arclin/acp039 PMid:19648582
  • Poole, M. L., Brodtmann, A., Darby, D. y Vogel, A. P. (2017). Motor speech phenotypes of frontotemporal dementia, primary progressive aphasia, and progressive apraxia of speech. Journal of Speech, Language, and Hearing Research, 60(4), 897-911. https://doi.org/10.1044/2016_JSLHR-S-16-0140 PMid:28289749
  • Quilis, A. (1981). Fonética acústica de la lengua española. Madrid: Gredos.
  • R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
  • Ramus, F., Nespor, M. y Mehler, J. (1999). Correlates of linguistic rhythm in the speech signal. Cognition, 73(3), 265-292. https://doi.org/10.1016/S0010-0277(99)00058-X
  • Reyes, B. A. (2007). Prepositional processing in Spanish speakers with aphasia: The role of semantic value and amount of contextual information. En J. G. Centeno, R. T. Anderson y L. K. Obler (Eds.), Communication Disorders in Spanish Speakers: Theoretical, Research, and Clinical Aspects (pp. 183-197). Berlin: De Gruyter Mouton. https://doi.org/10.21832/9781853599736-017 PMid:17722485
  • Robin, D. A., Solomon, N. P., Moon, J. B. y Folkins, J. W. (1997). Nonspeech assessment of the speech production mechanism. En M. R. McNeil (Ed.), Clinical Management of Sensorimotor Speech Disorders (pp. 49-62). New York: Thieme.
  • Robles Bayón, A. (2019). Demencias degenerativas: ¿un dilema de síndromes o de enfermedades? Neurología. En prensa. Disponible en línea 19/07/19. https://doi.org/10.1016/j.nrl.2019.03.016 PMid:31331676
  • Rohrer, J. D., Rossor, M. N. y Warren, J. D. (2010). Syndromes of nonfluent primary progressive aphasia: A clinical and neurolinguistic analysis. Neurology, 75(7), 603-610. https://doi.org/10.1212/WNL.0b013e3181ed9c6b PMid:20713949 PMCid:PMC2931766
  • Russo, G., Russo, M. J., Buyatti, D., Chrem, P, Bagnati, P., Fernández Suárez M., … y Knopman, D. S. (2014). Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration. Journal of the Neurological Sciences, 344(1-2), 63-68. https://doi.org/10.1016/j.jns.2014.06.024 PMid:25015844
  • Savage, S., Hsieh, S., Leslie, F., Foxe, D., Piguet, O. y Hodges, J. R. (2013). Distinguishing subtypes in primary progressive aphasia: application of the Sydney language battery. Dementia and Geriatric Cognitive Disorders, 35(3-4), 208-218. https://doi.org/10.1159/000346389 PMid:23467307
  • Saxon, J. A., Thompson, J. C., Jones, M., Harris, J. M., Richardson, A. M., Langheinrich, T., … y Snowden, J. S. (2017). Examining the language and behavioural profile in FTD and ALS-FTD. Journal of Neurology, Neurosurgery and Psychiatry, 88, 675-680. https://doi.org/10.1136/jnnp-2017-315667 PMid:28596248 PMCid:PMC5537548
  • Shelley, B. P., Hodges, J. R., Kipps, C. M., Xuereb, J. H. y Bak, T. H. (2009). Is the pathology of corticobasal syndrome predictable in life? Movement Disorders: Official Journal of the Movement Disorder Society, 24(11), 1593-1599. https://doi.org/10.1002/mds.22558 PMid:19533751
  • Strong, M. J., Abrahams, S., Goldstein, L. H., Woolley, S., Mclaughlin, P., Snowden, J., ... y Rosenfeld, J. (2017). Amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18(3-4), 153-174. https://doi.org/10.1080/21678421.2016.1267768 PMid:28054827 PMCid:PMC7409990
  • Takakura, Y., Otsuki, M., Sakai, S., Tajima, Y., Mito, Y., Ogata, A., … y Nakagawa, Y. (2019). Sub-classification of apraxia of speech in patients with cerebrovascular and neurodegenerative diseases. Brain and Cognition, 130, 1-10. https://doi.org/10.1016/j.bandc.2018.11.005 PMid:30622034
  • Vergis, M. K., Ballard, K. J., Duffy, J. R., McNeil, M. R., Scholl, D. y Layfield, C. (2014). An acoustic measure of lexical stress differentiates aphasia and aphasia plus apraxia of speech after stroke. Aphasiology, 28(5), 554-575. https://doi.org/10.1080/02687038.2014.889275
  • Vogel, A. P., Fletcher, J. y Maruff, P. (2014). The impact of task automaticity on speech in noise. Speech Communication, 65, 1-8. https://doi.org/10.1016/j.specom.2014.05.002
  • Vogel, A. P., Poole, M. L., Pemberton, H., Caverlé, M. W., Boonstra, F. M., Low, E., ... y Brodtmann, A. (2017). Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype. Neurology, 89(8), 837-844. https://doi.org/10.1212/WNL.0000000000004248 PMid:28733335
  • Williams, D. R., y Lees, A. J. (2009). Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. The Lancet Neurology, 8(3), 270-279. https://doi.org/10.1016/S1474-4422(09)70042-0
  • Wilson, S. M., Henry, M. L., Besbris, M., Ogar, J. M., Dronkers, N. F., Jarrold, W., Miller, B. L. y Gorno-Tempini, M. L. (2010). Connected speech production in three variants of primary progressive aphasia. Brain, 133(7), 2069-2088. https://doi.org/10.1093/brain/awq129 PMid:20542982 PMCid:PMC2892940
  • Yunusova, Y., Graham, N. L., Shellikeri, S., Phuong, K., Kulkarni, M., Rochon, E., ... y Green, J. R. (2016). Profiling speech and pausing in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). PLoS ONE, 11(1). https://doi.org/10.1371/journal.pone.0147573 PMid:26789001 PMCid:PMC4720472
  • Ziegler, W. (2002). Task-related factors in oral motor control: Speech and oral diadochokinesis in dysarthria and apraxia of speech. Brain and Language, 80(3), 556-575. https://doi.org/10.1006/brln.2001.2614 PMid:11896657