Publicaciones (42) Publicaciones de MARIA JOSE MORCILLO ORTEGA

2015

  1. Diagnostic and assessment of specific and transversal competences in Chemistry studies in a distance education program

    1ST INTERNATIONAL CONFERENCE ON HIGHER EDUCATION ADVANCES (HEAD'15)

2014

  1. La innovación docente en Ciencias. Una realidad validada

    VII Jornadas de Redes de Investigación en Innovación Docente de la UNED: libro de actas

2005

  1. Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT1AR agonists with selectivity over α1- adrenoceptors

    Journal of Medicinal Chemistry, Vol. 48, Núm. 7, pp. 2548-2558

2004

  1. Serotonin 5-HT 7 receptor antagonists

    Current Medicinal Chemistry - Central Nervous System Agents, Vol. 4, Núm. 3, pp. 203-214

  2. Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT 1A/5-HT 3 ligands

    Bioorganic and Medicinal Chemistry, Vol. 12, Núm. 19, pp. 5181-5191

2003

  1. Optimization of the Pharmacophore Model for 5-HT 7 R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

    Journal of Medicinal Chemistry, Vol. 46, Núm. 26, pp. 5638-5650

  2. Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2- a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 8, pp. 1429-1432

  3. Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 19, pp. 3177-3180

2002

  1. 5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.

    Current topics in medicinal chemistry, Vol. 2, Núm. 6, pp. 625-641

  2. Arylpiperazine derivatives acting at 5-HT1A receptors

    Current Medicinal Chemistry, Vol. 9, Núm. 4, pp. 443-469

2001

  1. Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist

    Pharmacology, Vol. 62, Núm. 4, pp. 234-242

  2. Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT1A/α1-adrenergic receptor affinity: Synthesis of a new derivative with mixed 5-HT1A/D2 antagonist properties

    Journal of Medicinal Chemistry, Vol. 44, Núm. 2, pp. 186-197

  3. Synthesis and structure-activity relationships of a new model of arylpiperazines. 6. Study of the 5-HT1A/α1-adrenergic receptor affinity by classical Hansch analysis, artificial neural networks, and computational simulation of ligand recognition

    Journal of Medicinal Chemistry, Vol. 44, Núm. 2, pp. 198-207

2000

  1. Erratum: Corrigendum to 'First pharmacophoric hypothesis for 5-HT 7 antagonism' (Bioorganic and medicinal chemistry letters (2000) 10 (1097) PII: S0960-894X00001669)

    Bioorganic and Medicinal Chemistry Letters

  2. First pharmacophoric hypothesis for 5-HT 7 antagonism

    Bioorganic and Medicinal Chemistry Letters, Vol. 10, Núm. 10, pp. 1097-1100

1999

  1. Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors

    Journal of Medicinal Chemistry, Vol. 42, Núm. 24, pp. 5020-5028

  2. Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

    Bioorganic and Medicinal Chemistry, Vol. 7, Núm. 11, pp. 2271-2281

  3. Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl)piperazin- 1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2c]imidazole (EF-7412) using neural networks. A selective derivative with mixed 5-HT(1A)/D2 antagonist properties

    Bioorganic and Medicinal Chemistry Letters, Vol. 9, Núm. 12, pp. 1679-1682

  4. Synthesis and structure-activity relationships of a new model of arylpiperazines 4. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9h-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

    Journal of Medicinal Chemistry, Vol. 42, Núm. 1, pp. 36-49

1998

  1. 1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT(1A) receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

    Bioorganic and Medicinal Chemistry Letters, Vol. 8, Núm. 6, pp. 581-586